12/3/2023 0 Comments Triglycerides normal range child![]() ![]() In the Muscatine study ( 18), increased BMI and blood pressure and decreased HDL correlated with the early development of coronary calcification, considered a marker for atherosclerosis. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study ( 3) reported that LDL cholesterol, severe obesity, and elevated glycohemoglobin levels were significantly correlated with the postmortem diagnosis of coronary atherosclerosis in 15- to 35-year-olds ( 17). For example, in the Bogalusa studies, antemortum total and LDL cholesterol levels, blood pressure, BMI, and fasting insulin were all positively correlated with aortic and coronary artery fatty streaks and plaques ( 1, 2). High serum total cholesterol, LDL cholesterol, very-low-density lipoprotein (VLDL) cholesterol levels, and low HDL cholesterol levels are correlated with the extent of early atherosclerotic lesions in adolescents and young adults. QUESTION 3: DOES ATHEROSCLEROSIS BEGIN IN CHILDHOOD? IS THIS RELATED TO DYSLIPIDEMIA?Īutopsy studies demonstrate that aortic and coronary atherosclerosis are commonly seen before age 20 years ( 1– 3). ![]() The tracking correlation coefficients for dyslipidemia suggest that most but not all children with lipid abnormalities will have them as adults ( 14). For example, the development of obesity in childhood predicts a similarly elevated weight as an adult. Data from the Bogalusa Heart Study ( 1) and the Muscatine study ( 14), however, clearly show that cholesterol and other cardiovascular risk factors often persist from childhood to adulthood. This is in part related to the dramatic decrease in total cholesterol seen as children progress through puberty ( 16). While most children with high cholesterol levels will also have high levels as adults, some children with high levels will have normal levels as young adults. In the general population, total cholesterol levels are generally 40 mg/dl higher in adults than in childhood. Children and adolescents with high cholesterol levels are more likely than the general population to have high levels when they become adults ( 14, 15).
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